Tottenham's first Premier League match at Wembley is against Chelsea on the second weekend.
United's first significant test in their attempt to improve substantially on last season's sixth-place finish comes courtesy of a trip to Liverpool on October 14, and a home game versus Arsenal and Mourinho's nemesis Arsene Wenger on April 28 figures to be particularly important to any title or Champions League aspirations.
Chelsea will open the defence of their Premier League title at home to Burnley when the season kicks off on the weekend of August 12-13.
Key to Tottenham's title hopes will be a five-week spell starting on October 21, which sees Spurs take on Liverpool, Manchester United, Crystal Palace and Arsenal. Sandwiched between the Champions League Round of 16 legs, Chelsea have back-to-back away matches against the Manchester clubs.More news: Strong start to summer driving season pushed US oil rises towards $50
Tottenham will be the home side, but they will be getting used to their new surroundings as they play at Wembley while White Hart Lane is rebuilt.
The fixtures for the 2017/2018 campaign were released on Wednesday morning, with both London clubs quick to point out they would need to seek alternative arrangements for certain matches.
The Premier League season begins on August 12.
City also have a huge amount of time before they face any of the top sides, allowing their new signings to settle, with Chelsea away on the seventh weekend of the season their singular visit to one of last season's top seven before December hits.
Chelsea won both August home fixtures 3-0, and a season-opener away 3-1.