The analysis also offers clarity to wavering Senate Republicans on whether to vote for the bill later this week.
The release of the budget office's analysis comes as a number of reluctant Republican senators weigh whether to support the health bill, which the majority leader, Mitch McConnell of Kentucky, wants approved before a planned recess for the Fourth of July.
That is a tough pill for moderate Republicans, who will be under enormous pressure from their constituents to vote against the bill.
Sen. Susan Collins, R-Maine, who has expressed strong concerns about the measure, had been waiting for the CBO score before making a decision about her position.
Although people buying insurance in the individual market would see lower premiums in many cases, the policies would cover less, and out-of-pocket costs would be higher.
Also, senators would eliminate the mandates that require almost all Americans to have coverage and companies with more than 50 workers to provide health benefits.
The Senate bill does more to reduce the federal budget deficit compared to its counterpart in the House of Representatives. Insurers need large numbers of healthy people to help pay for those who are sick.
The bill is not expected receive support from Democrats.
A handful of Republican governors, including Nevada's Brian Sandoval and Ohio's John Kasich, have come out against the bill.
The Democrats have become nothing but OBSTRUCTIONISTS, they have no policies or ideas. They say the bill doesn't go far enough if repealing Obama's 2010 statute. By Friday afternoon, he was facing public statements of opposition from five GOP senators - three more defections than he can afford and still win approval for the legislation over united Democratic opposition. Many people who had gotten comprehensive Medicaid coverage would have to fall back on the shoddier individual insurance market described above.
Johnson is among four conservatives and a moderate who said they don't back the measure but haven't ruled out supporting it if it's changed.
Doctors, nurses, patients and activists listen to Senate Minority Leader Chuck Schumer, D-N.Y., speak about Senate Republicans' health care bill on Friday at Bellevue Hospital in New York City.
The Senate health-care bill would result in 22 million more uninsured Americans over the next decade compared with the current law. All they do is delay and complain. (Federal Medicaid funds are already prohibited form being used for most abortions.) The bill would also block subsidies from going to insurance plans that include abortion coverage. Spicer said the president spent the weekend calling several senators, including Cruz, Paul and Johnson, as well as West Virginia Sen.
The provision "would pour salt in that wound, locking American families out of health insurance for even longer, thanks to this six-month ban provision", he said.
But if pressure increases and two more senators look like hard "no" votes, then you'll probably see lots of senators abandon it, not wanting to be associated with something that was not only so substantively very bad but also carries the stench of defeat.