Querrey, who ended Novak Djokovic's title defence previous year, took advantage of Sir Andy's injury problems to clinch a 3-6, 6-4, 6-7, 6-1, 6-1 triumph on Centre Court at the All England Lawn Tennis Club.
A year ago he dumped out Novak Djokovic and his monstrous serve and powerful ground strokes proved too much for injury hit Murray to handle. "I managed to get through a bunch of matches but now with the US Open seven weeks away I have to sit down with my team and come up with a plan about what to do next".
By the fourth set Murray was noticeably limping, grimacing and complaining to his players' box.
"I'm still in shock myself", Querrey, 29, said after the match. I'm proud of that.
Querrey, who faces seventh seed Marin Cilic in the semi-finals on Friday, said he was not distracted by Murray's injury issues. Today we will be able to watch all four of the matches, with the action starting out with Murray vs Querrey on Center Court and Muller vs Cilic on Court 1, followed by Raonic vs Federer on Center Court, and Berdych vs Djokovic on Court 1 directly after. Novak Djokovic and Andy Murray were eliminated from this year's tournament after they both had excessive troubles with injuries.
As for Murray's prospects, Hewitt is more optimistic now than he was prior to the tournament, when for a couple of days at least there was doubt over whether the world No.1 would be fit to compete. I didn't start my best. I just need to do all of the right things and be even more diligent and professional than I have been recently'.
Murray's hopes of becoming the first British player to retain a grand slam title since Fred Perry in 1936 were dashed by a hip injury and world No 24 Querrey, who prevailed 3-6, 6-4, 6-7 (4-7), 6-1, 6-1 to set-up a semi-final with seventh seed and 2014 US Open victor Marin Cilic. The rest of the set saw a dominance of the Swiss maestro. You know, gave everything I had. I'm sure Rafa will come back very strong.
"For the most part I just try to worry about what I'm doing".
Raonic was beaten by Andy Murray two days later while Federer reacted by taking six months off to recover from a niggling knee problem. "It feels great. I'm going to enjoy this one a little bit tomorrow and have an easy day tomorrow". In 2013 he was broken four times and in 2016 three times over the first four rounds. Czech world No 15 Berdych, the 2010 Wimbledon runner-up, goes on to face Roger Federer for a place in Sunday's final.