The Seagulls coasted to promotion last season and their credentials will immediately be tested against Pep Guardiola's big-spending side.
If City find themselves easily turned over by a fast counter-attacking team - let's say Tottenham Hotspur, who caused Guardiola problems last season - then Stones, Otamendi and one other will holding off Kane, Alli, Son, Eriksen et al.
So what might their starting XI look like for their first match of the new campaign?
The full-back positions appear to have been locked down by the acquisition of Benjamin Mendy and Kyle Walker, although Brazilian Danilo may challenge for a starting berth and it seems as though it is further up the pitch that City now need to look.
City will travel to Spain for a brief training camp after the home clash with Brighton on Saturday before they face Girona FC.
And after Phil's eye-catching performance against Man United in pre-season, Pep couldn't hide his awe at the teenager's ability, saying: "It's a long time since I saw something like this".
Mendy's injury at left-back means Danilo - traditionally a right-back - will fill in for the France worldwide, with Walker on the other side of the pitch.More news: Can Liverpool work their way up to PL Champions this season?
"We have had some players away on worldwide duty this summer, which means Pep hasn't had the chance to work for long with the whole squad".
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Is central midfield strong enough? Davy Propper, Matt Ryan, Pascal Gross and Isaiah Brown are all expected to improve the quality of the squad, while Glenn Murray, Anthony Knockaert, Tomer Hemed and veteran Bruno Saltor should help with their extensive experience.
Beram Kayal will miss up to 12 weeks after fracturing his fibia, while Sam Baldock (calf) has also been ruled out. He scored the victor in a Europa League qualifying match this month.
"It's a wonderful game for the club and supporters, as a first game in the Premier League, but we have to make sure it's a good day for the team as well", said Hughton.
Busquets against Manchester City's David Silva in the Champions League.