Oklahoma cracked the top 5 at No. 5 after beating UTEP on Saturday.
Ohio State is 27-4 in games Barrett has started the last four seasons.
Weber, a 1,000-yard rusher as a redshirt freshman previous year, practiced Monday at full speed.
All college football odds and betting trends courtesy of Bleacher Report's official odds partner, OddsShark.
"We just need to keep getting him the ball", Oklahoma quarterback Baker Mayfield said. If the opener against IN is any indicator, he could quite possibly do just that.
Ohio State's passing game was not good last year and it is still unproven this year.
Ignition Casino is our most recommended ONLINE CASINO and POKER ROOM for both United States of America players and worldwide players alike. "That will be our main focus". He had two interceptions, which led to 14 points for the Buckeyes.
Moreover, the No. 6 Penn State Nittany Lions could be the biggest challenger to Ohio State. Oklahoma State 12. LSU 13. "It's all about right now".
In addition to Mayfield, Oklahoma features an offensive line ranked the best in the country by Phil Steele's College Football Preview.
"Our approach to this game is it's the biggest game of the year", he said. Rivals.com National Recruiting Analyst Adam Gorney lays out the situation and then receives takes from Rivals.com National Recruiting Director Mike Farrell and a local expert from the Rivals.com network of team sites. We have to prepare that way.
"Everybody who was here for last year's huge loss definitely remembers that".More news: Some Hispanic Texans Support Ending DACA Program
The Sooners weren't tested in their opener last Saturday against Texas-El Paso, rolling to a 56-7 win at home.
A year ago, Mayfield completed 17 of 32 passes for 229 yards and two touchdowns against Ohio State. While Lagow is a talented pocket passer, IN chose to use quicker passes to help negate Ohio State's pass rush.
The Buckeyes' area of vulnerability could be the secondary. The Buckeyes actually trailed the Hoosiers 21-20 with about five minutes left in the third quarter. "I know coach Bob Stoops very well. The defensive line played outstanding".
For most of the season opener at Indiana, Ohio State's defense struggled to slow down Hoosiers quarterback Richard Lagow and wide receiver Simmie Cobbs.
Urban Meyer was once the hot young coach. Meanwhile, the Buckeye defense forced three IN turnovers.
"They are excellent", Meyer said about the OU offense. "I told somebody this morning that I don't think that has much of an effect on it". "And it was hard for me not to walk down after the game and just say: 'Dudes, what are you doing?"
NOTES: Oklahoma will be without CB Jordan Parker.
Weber rushed for over 1,000 yards as a redshirt freshman last season but was hampered by a hamstring injury throughout preseason camp.
Ohio State is 3-0 ATS in its last three games in September.
Ohio State football is the No. 1 topic in Wake Up Sloopy every day - but we cover news, notes and analysis from across Buckeyes sports. The Sooners are ranked 5th in the nation.