Liverpool are the favourites to get the win at the price of 4/6.
Kick-off is at 7.45pm.
What TV channel is it on?
The teams are due to kick off at 2.45 E.T. and the game will be shown on Fox Deportes, while also being live streamed at fuboTV.
Coverage will begin at 7pm and the programme will finish at 10.15pm. Follow the live blog on rte.ie/sport from 7pm.
Meanwhile, Liverpool will be disappointed to go behind so early against Sevilla.
"We have to enjoy the tournament, because it is a special tournament, the biggest in Europe, and we have to ensure we enjoy being here", said Klopp.
Liverpool and Sevilla's only previous encounter came in the final of the 2016 Europa League. A great chance for 3-1 denied.
He said: "Leaving Coutinho out against City was a decision made with the season in mind". After all, they have been waiting for this moment for a long time.
"The most important thing for me to say is not even one per cent of Sadio wanted to bring the goalkeeper in danger". They have won two of their first three league games and drew the other.
"I will have this situation all the time over the next three or four weeks, so we thought: "OK, let's start immediately with this, give him three or four days of training and then he's available for us". After a draw in the home match with "Hispaniol" - 1: 1, "Sevilla" won away "Getafe" - 1: 0 and defeated "Eibar" in his field - 3: 0.
bet365 Sports has offered some of the best odds surrounding the Champions League Group Stage and tonight is no different.
Only Marco Verratti (479) completed more passes than Sevilla midfielder Steven N'Zonzi (459) in last season's Champions League group stages.
The only meeting of the teams in question fell at the finals of the Europa League of 2015.