Marouane Fellaini will be the man to step into midfield while left-back Luke Shaw is also available but has failed to make the match-day squad.
Back-to-back 3-0 losses - to Tottenham in the league and Atalanta in the Europa League - over the past week followed Everton's lacklustre 2-0 defeat at Chelsea before the two-week break for internationals. Captain Phil Jagielka returned to the side along with Tom Davies meaning Sandro and Davy Klaassen dropped to the bench.
"He'll be a little bit concerned about the goals they conceded at Stoke last week and a couple of good chances they conceded today". It took until midway through the first half before the hosts were given a scare, though the returning Wayne Rooney could only drag Cuco Martina's low cross wide of David de Gea's far post.
No other Everton forward has made more key passes per 90 minutes than Calvert-Lewin, so retaining him in the XI for the Red Devils clash looks to be an obvious starting point as Koeman bids for an improved performance.
With over 250 senior club appearances to complement his 60 global caps, Lukaku has already scored over 100 senior career goals, and his future career figures are already set to be simply frightening.
"I think Jose's always renowned as being a patient coach, his team look like they have the maturity to be able to handle it".
Substitute Anthony Martial then added a fourth from the penalty spot after Morgan Schneiderlin's handball to give United an equal record to league leaders Manchester City. No goals scored, eight conceded.
United entertain Burton in the Carabao Cup on Wednesday night, again at Old Trafford, before next Saturday's Premier League assignment is away to Southampton.