As usual in this fixture, it was Real with most of the possession and the greater share of the play, but Atletico had the better chances overall in the 0-0 draw.
The sides head into the 161st league instalment of this fixture locked on 23 points apiece, already eight adrift of leaders Barcelona who have made a near-perfect start.
The visitors struggled to create chances in battling to a second blank of the season and first on the road in 35 top-flight matches.
That is how they have built the legend, being proclaimed the best club of the 20th century and collecting more trophies than any other team in football history.
Nevertheless, the score remained goalless at the halftime break. He was replaced by Nacho.
Should Atletico avoid defeat to their neighbours this evening, it will mark their longest unbeaten run to start a league campaign, but that does not quite tell the whole story.
Luka Modric in action during the UEFA Champions League group H match between Real Madrid and Tottenham Hotspur at Estadio Santiago Bernabeu on October 17, 2017 in Madrid, Spain.
The main difference from previous years is that for some unknown reason the fire that encouraged the players to deliver their last drop of energy seems to have disappeared. "I'm sure we will cut the distance".
Gabi fired a speculative long-range volley off target midway through the first half before the visitors hit their stride and carved out a number of clear opportunities to take the lead.
Atletico were again left to rue their lack of ruthlessness in front of goal as Angel Correa and Griezmann's replacement Kevin Gameiro passed up the best chances of a tightly-contested derby. I feel bad for the players because they deserved more from that.
"The draw was a fair result", Simeone said.
It was another frustrating night for Madrid talisman Cristiano Ronaldo, who still has just one goal in La Liga this term, while in general the team lacked spark in attack. And neither is celebrating following their biggest match of the season so far.
Meanwhile, Zinedine Zidane will be without the services of Gareth Bale and Keylor Navas. Suarez hadn't scored in more than a month.
It may not quite be an unbridgeable gap, with only 12 games gone, but it is firmly advantage Barca.
Paulinho sealed the victory in the 90th after a pass by Messi, who was on the ground fighting for the ball when he tipped it back to the midfielder.