The Blues needed to win to be sure of the number one position in their group.
Saturday's trip to the London Stadium marks the opening game in this weekend's round of fixtures and a Chelsea victory would lay down a marker before City meet second-placed United in the Manchester derby the following day.
The 2017/18 Champions League group stage saw a total of 306 goals scored; the most in a group stage campaign in competition history.
They will be joined in the knockout stages by Juventus, who won by the same score at Olympiacos with Juan Cuadrado and Federico Bernardeschi on the scoresheet. The first legs will be played on 13, 14, 20 and 21 February, with the return legs set to be played on 6, 7, 13 and 14 March 2018.
Celtic claimed a Europa League berth by finishing third but did so in a disappointing fashion as they lost 1-0 at home to Anderlecht.
Chelsea were already through to the knockout stages, but blew their chance to finish in first place and in theory earn an easier draw.
The Brazilian winger Bernard has long been a talent who could play at a higher level than the Ukrainian league and showed it again during Manchester City's visit.
The German club were unable to cope with fellow big-hitters Tottenham and Real Madrid in their group and were also unable to beat Cypriot side Apoel Nicosia in either of their two ties. His hat trick - a penalty, a slide-rule left-footer and a deflected effort - was part of a dazzling all-round display the Russians simply could not handle.
"Don't forget here this season is very tough". Yes, it was, in fact, Lionel Messi and Cristiano Ronaldo (prediction: they may just be the first to reach 70).
"We tried to play our game".
The move to their new Wanda Metropolitano stadium was designed to herald a fresh period of success for Atletico Madrid, but Diego Simeone's side's streak of four straight runs to at least the Champions League last eight was abruptly ended.
Christensen should have equalised from a Cesc Fabregas cross 10 minutes later, but the Chelsea defender somehow headed wide of the open goal.