A wintry mix will also be possible in the north part of central Alabama, according to the weather service, but forecasters said that a significant impact doesn't seem likely.
He expects the area will get some rain in the morning followed by a mixture of sleet and freezing rain.
A Winter Storm Watch has also been issued for parts of Middle Tennessee from 6 a.m. until midnight Friday.
The precipitation will usher in cold and blustery conditions. Temperatures stay well below freezing through the weekend, with highs only in the low to mid 20s.
The winter warning lasts through 1 p.m. Saturday.
Roads could become hazardous in the Shoals by 9 a.m., Metro by 11 a.m., NE Alabama by 1 p.m.
As temperatures drop on Friday, rain will transition to a freezing rain/sleet/snow mix before changing to all snow later in the day. Chance of precipitation is 100%.
"Snow accumulations of 2" - 4" is possible for most valleys and up to a foot or more over Lookout Pass.
The snow will be accumulating on already icy roads from overnight rains and sleet, coupled with strong northwesterly winds adding to the freezing threat.
Snowfall Expected Thursday.Snow will fall across the area starting late tonight and continuing into Thursday.
ADDITIONAL DETAILS.Winds gusting as high as 30 miles per hour will cause areas of blowing and drifting snow, especially on ridge tops and in open areas.
Ice accumulations may be greatest in the Southern Tier and Genesee Valley with totals nearing a quarter of an inch. Cloudy, with a high near 19. Southwest wind 3 to 6 miles per hour. That could take the form of heavy sleet, snow, ice, blowing snow or a combination of those conditions.
"Upper 50s around 60 (degrees) for the highs today has melted much of the snow", he said.
Sunday, that means lows in the single digits and highs in the teens. Lows Thursday and Friday night will be well below zero.
Saturday night, it will be partlyl cloudy, with a low of 8, according to the weather service. Chance of precipitation is 40 percent.