Pep Guardiola's side go into the clash as heavy favourites.
Much will depend on whether Wenger can lead the club back into the Champions League.
Arsene Wenger has warned his Arsenal players: qualify for the Champions League or you could be axed.
Arsenal head in to tomorrow's game knowing anything other than a win would all-but end our hopes of finishing in the top four as we're now 10 points adrift of fourth-placed Tottenham. The Gunners' sole hope of silverware now rests on the Europa League, where they face Italian giants AC Milan in the round of 16. If he cared, Wenger would not have got a two-year deal. In this rearranged league meeting, originally due for last weekend before both sides made it to the Carabao Cup final, Wenger and his players have a chance to show than can mix it with the best team in the country.
'It is understood there is a feeling among Arsenal's squad that Wenger is no longer the man to take the team forward.
Fans can be an ungrateful bunch with short memories and the rush to seek a manager's head when things aren't going well is one of the nastier elements to the modern game.More news: Buy Samsung Galaxy S9, S9+ for as low as Dh128 in UAE
"I think everyone recognises how hard it is with City performing so well this year". That being said I can't accept some of the decisions that went against us yesterday.
The difference is that Guardiola is a serial victor, lifting 21 trophies in his first seven years of senior management with Barcelona and Bayern Munich.
Guardiola has also demonstrated a far shrewder sense of timing than Wenger in knowing when to walk away. They are basically Everton from last season.
Though this season's title has looked like a foregone conclusion for some time, Wales manager Giggs acknowledged that the mindset alters once you become the reigning champions.
The competition that Arsene Wenger has treated virtually as an afterthought this season could end up being his savior. Ozil didn't at Wembley, having just one touch in the opposition's box and, while he was not one the worst performer on the day, will naturally take greater flack, particularly in the wake of his new bumper £350,000-a-week contract.
"They're looking good", Giggs said.
It may be the only thing remaining that Wenger holds over English football's new dominant power.