The following season, under Jose Mourinho, he featured 53 times in all competitions, scoring 11 goals and creating a further six for his teammates.
Pogba wasn't named in the match day squad after picking up an injury in training on Friday, prompting Mourinho to name Scott McTominay and Nemanja Matic in his midfield.
The players who are certain to miss the tie are Ander Herrera (hamstring), Marcos Rojo (knock), Phil Jones (knock), Daley Blind (ankle) and Zlatan Ibrahimovic, although the Swede has returned to training.
The native of Manchester is presently enjoying his third season as a senior United player.
Sevilla are now placed fifth in the Spanish league table, eleven points behind fourth placed Valencia. There were, however, wins against both Malaga and Athletic Bilbao in between that sandiwch of defeats.
"Seville and Brighton are more important games than Liverpool", Mourinho said on Saturday.
"The good thing was the first chance he had, he got it, he scored because I think in the last two months that was not happening with him", Mourinho said of Rashford. After Mourinho came out after the Liverpool game criticising the fans who booed McTominay for his "negative" play', it will be interesting to see how the youngster deals with the pressure of a Champions League knockout fixture. Manchester City enjoy a 13-point lead at the top of the Premier League with a game in hand.More news: Rusia podría estar detrás de la muerte de ex espía
Son was entrusted to move into the centre-forward role once Kane departed and showed he can deputise for Spurs' talisman with his sixth and seventh goals in his last four games to take his tally for the season to 18.
The former Watford and Aston Villa man has earned an England recall this season and was praised for his man-of-the-match performance at full-back during United's 2-1 Premier League victory against Liverpool on Saturday.
Manchester United have turned their form around and how, since the first leg in Seville.
In addition, Lingard will incur a suspension on his next Champions League yellow card and, given Rashford's brace against Liverpool, you'd think Mourinho would want to give the in-form boy wonder the nod.
Midfielder Paul Pogba remains a doubt, however, as United try to capitalise on the 0-0 draw in the first leg in Spain. That means United must win.
Manchester United may enjoy home ground advantage in the second leg of their Champions League last-16 tie against Sevilla today but manager Jose Mourinho admitted yesterday that the tie is evenly balanced.