Bale has 11 goals in 21 La Liga starts so far in an injury affected 2017-18, but the 28-year-old has only started two Champions League matches all season and was benched by coach Zinedine Zidane for both round-of-16 games against Paris Saint-Germain and the quarter-final first leg against Juventus.
The 3-0 loss to Real would've come as a shock to Juve, who had previously gone 23 matches unbeaten in all competitions.
Defender Giorgio Chiellini believes that, at the very least, a strong performance at the home of the reigning champions would be beneficial for Juventus' next European campaign.
"We know we have to be prepared to win, it'll be hard".
Los Blancos take a 3-0 lead into the game after Cristiano Ronaldo scored twice and Marcelo once to put the 12-time European champions in the driving seat.
Sunday's draw saw Real slip to fourth in La Liga, behind Valencia and second-place Atletico, with league leaders Barcelona 15 points ahead of Zinedine Zidane's team. Real blanked Juventus, 3-0, in the first leg of their quarterfinals match in Turin last week.
"It will also be important that we also play a defensive game since we know that Real Madrid have the experience to know that anything can happen in the game. It was a good game, but there is still 50 percent of the tie to be played", he said.
"I'm not interested in talk of favourites, I prefer to show it out on the pitch and we must respect all clubs and all aspects of football", added the Real boss.
"The whole world will be watching and we must play without thinking of regrets or what we could've done". We are regaining our confidence, the goals and our overall game. He's our all-time top scorer and represents all that we are: talent, work, sacrifice, professionalism and ambition.
All without their chief source of creativity in attack, Paulo Dybala, who is suspended after being sent off in the first leg. Lucas Vazquez and Jesus Vallejo are also doubts. Madrid can reach the semifinals for the eighth straight year even if it loses Wednesday's game by two goals.
History is certainly not on Juve's side. None of these sides have managed to overturn a three-goal deficit.
This could be Gianluigi Buffon's final Champions League appearance.
While Ronaldo was on target for Real, Atletico saw their own talisman offer an nearly immediate response to secure a share of the spoils.