De Bruyne, for all his attacking and creative talents, was a very close second while Harry Kane was finished third in the voting.
Salah has enjoyed a remarkable season since joining Liverpool from Roma last summer, scoring 41 goals in all competitions to date.
Having moved level with Alan Shearer, Cristiano Ronaldo and Luis Suarez, the 25-year-old now has three more games - against Stoke City, former club Chelsea and Brighton and Hove Albion - to add to his league haul.
He was voted as the division's best player in November, February and March.
"First of all, there's no comparison between Liverpool with our latest rival in the league", he said.
Salah still has the chance of winning the Champions League trophy, with Liverpool in the semi-finals of probably the world's most prestigious club tournament. The award was recognition of Regis' pioneering role in changing attitudes towards black footballers in England.
Salah's season will become more decorated if he helps the Reds to win the competition.More news: Feds investigating missing window on plane — UPDATE
But for City manager Pep Guardiola it is De Bruyne who should have been acclaimed due to his achievements over the course of the entire season.
"He is a fantastic player, up there with the world's best, and there will be other clubs who want to take him away", the England worldwide said.
"Maybe the numbers say someone is better than him but this season there has been no one better than him".
Salah claims that he always knew he would succeed in the Premier League, insisting that an unsuccessful spell on the books at Chelsea between 2014 and 2016 was down to his lack of opportunities under Mourinho.
City did pick up a prize from the PFA gala in central London on Sunday, though, as Leroy Sane won the Young Player of the Year.
"We take it game by game and I'm happy about that". Once again, we've not focused on specific players.
"I am really not interested in what people think", he said. "They are all really good guys and we work really hard". Off the field, he's a fantastic human and he has a great passion for football and you can see that with how we're playing. "I hope that Salah continues his successful journey, he has developed a lot in the last two seasons on both club and national levels".