Now Palestinians and Israelis must show restraint - and the USA must make a new diplomatic push - to prevent even more violence from engulfing the perpetually troubled region in the coming days.
"France calls on all actors to show responsibility in order to prevent further unrest", Le Drian said in a statement.
Although Trump has said his declaration does not set the final borders of the city, it is seen by both Israel and the Palestinians as taking Israel's side in the most sensitive issue in their conflict.
"Somewhere between zero and none", Dr Martin Indyk, a former U.S. special envoy for Israeli-Palestinian negotiations in the Obama administration, said of the chances President Donald Trump might bring the two sides together and broker what he has called the "ultimate deal".
"What was opened today in Jerusalem is not the USA embassy but an Israeli settlers' post", Palestinian President Mahmoud Abbas said. "Right now the peaceful negotiations are not going anywhere and will not go anywhere".
Israel has always been facing global criticism for its harsh response to mass Palestinian protests.
The Trump administration says it has almost completed a new Israeli-Palestinian peace plan but is undecided on how and when to roll it out.
Deri penned a letter to Netanyahu imploring him to seek a change in the longstanding US policy, hours after the opening of the new US Embassy in Jerusalem. "That's how previous administrations would deal with it".
Regarding violence that erupted on Monday and resulted in the deaths of 55 Palestinians, Shapiro placed the blame squarely on Hamas. This is a staggering toll", said Sanders, who explained that: "Hamas violence does not justify Israel firing on unarmed protesters.
Hamas tried to mar the occasion by inciting some of its benighted followers to a suicidal charge against the Israeli border. Meanwhile UN Secretary General Antonio Gutteres expressed his profound alarm at the "sharp escalation of violence" and the "high number of Palestinians killed and injured in the Gaza protests". Some threw stones, and organizers urged others to burst through the fence.
What seems more likely to me at the moment is a slower unravelling of the peace process framework which for the past 25 years has led to neither peace nor all-out war.
As gunfire broke through the protests, ambulances roared in and out. Those responsible for outrageous human rights violations must be held to account.
Christians George and Cheryl Morrison traveled from Colorado, and said they have never been more proud to be American.
Later in the White House briefing, Shah was asked when the White House last reached out to Palestinians.
"From King David's time to our own, President Trump has now etched his name into the ineffaceable story of Jerusalem", Pence said.
A 21-year-old and a 29-year-old were among the first killed by Israeli soldiers, according to the Gaza Health Ministry. Shah responded by saying: "Again, we believe that Hamas is responsible for this". The top diplomat turned his back and walked away.