A brace from Antoine Griezman and a goal from Gabi was enough for Partey's side to win the coveted trophy.
That paved the way for Griezmann to take centre stage, Marseille failing to truly threaten again until the latter stages when substitute Konstantinos Mitroglou hit the post with a header.
"I hope that he is happy to play for us".
The highly-rated French forward capitalised on an error to open the scoring in the first half before scoring the second goal in the second half, this time chipping the ball over the advancing Marseille goalkeeper Steve Mandanda.
France coach Didier Deschamps names his 23-man squad later today and top of his list will be Griezmann. "I left home when I was 14 for that". Hats off to Marseille, a great team. "I don't know how to describe the finish, perhaps cold-blooded".
"We found the first serious position in the match, we went to the opponent's level, but we couldn't spread it in 90 minutes".More news: OnePlus 6 Marvel Avengers Limited Edition announced
So Ligue 1 Conforama's Week 38 will be rich in suspense, with three sides battling it out for the two places behind champions Paris Saint-Germain.
Many social media users pointed to the enhanced security deployed to Lyon ahead of the landmark final.
No French team has ever won the Europa League title.
However, perhaps as a nod to the inevitable, Simeone thanked Griezmann for his service.
This may be less prestigious than the Champions League, but Simeone has now won six titles with the club, including a UEFA Super Cup and a Spanish Super Cup. "Even without him we'll continue to grow".
PSG will see it as returning the favour after OM fans rejoiced in Real Madrid knocking their Parisien rivals out of the Champions League in the round of 16.