However, he signed off 2017-18 on a note of bitter disappointment as a shoulder injury sustained in a grappling challenge with Sergio Ramos saw the 26-year-old substituted 30 minutes into last month's 3-1 Champions League final defeat to Real Madrid.
He was an unused substitute in Egypt's first group game at the World Cup - a 1-0 loss against Uruguay on Friday.
They will bang their hope on a miracle, an unlikely victory by Saudi Arabia against Uruguay in Group A's other game on Wednesday, if they are to stay in the tournament.
"Egypt's game with Salah is different from the one they play without him", forward Alexei Miranchuk said.
Tuesday's early game sees Colombia take on Japan in Saransk, 4 years after pounding the Asians 4-1 at the 2014 World Cup. I played against [Egypt head coach Hector] Cuper's teams before, he is the most tactical coach, you never know how to approach his teams.
And the Egypt worldwide had to watch on as Uruguay claimed a 1-0 win over his side in their group stage opener.More news: Mohamed Salah injury: Egypt reveal why Liverpool star missed Uruguay defeat
Egypt coach Hector Cuper told reporters the team's medical staff had assured him before the match that Salah was "fit and feeling good".
Egypt are set up to play on the counter-attack, with Cuper asking his midfielders and defenders to stick close together in two rigid banks of four and restrict the spaces that opponents seek to exploit.
Everything in this match comes down to Salah returning for Egypt and taking the pitch in decent fitness.
He has scored 33 goals in 57 appearances for Egypt and was their top scorer in FIFA World Cup qualifying, sealing their place in Russian Federation with a stoppage-time penalty against Congo that sparked wild celebrations in the football-mad country.
A needless punch from goalkeeper Mohamed El-Shenawy led to a horror own goal from Ahmed Fathi in the 47th minute. They can not sacrifice points against either if they hope to avoid joining South Africa as the only hosts to miss getting out of their group.