The final matches of the group stages kick off today, with action in Group A and Group B.
Here is where things stand in each group going into final round-robin matches..
Ronaldo, who looks a favourite to win a sixth world player of the year award, will be desperate to top the goalscoring charts in Russian Federation.
Despite earning all the plaudits Cristiano Ronaldo and Portugal could be sent packing from Russian Federation 2018 tonight, KickOff.com takes a look at the group stage permutations going into the third and final round of fixtures.
At the moment Spain and Portugal lead the group on 4 points with Iran just one point back on 3. Portugal take on Iran in the other match.
All matches can be streamed via Fox Sports Go in the United States.
Australia need to beat Peru, also at 2am, and hope Denmark lose. Since Denmark and Australia drew, they too could be split by fair play. Win and they're through.
Group victor plays runner-up in Group D. Runner-up plays Group D victor. Messi's men have to beat the Super Eagles to move onto four points, giving themselves a chance of progressing. Serbia can still make it if they beat Brazil or draw while Switzerland are beaten by a couple of goals.
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Identical records would then see qualification decided by the better result when the teams met, which would see Germany go through courtesy of their 2-1 win.
Nigeria will qualify with a win over Argentina.
If both win, they would tie, level on seven points and it would come down to goal difference, with that now level too. Goals scored is the next criteria, followed by the head-to-head record of the tied teams.
Group victor plays runner-up in Group A. Runner-up plays Group A victor.More news: 'I really don't care': Melania Trump jacket stuns on migrant visit
Brazil, Switzerland and Serbia are in contention for the two places.
For a while in the second-half of their match against Costa Rica, it looked like pre-tournament favourites Brazil might crash out of the Group Stage.
The winners of Group E face the second-placed team in Group F.
Uruguay, the favorite to win the group, got past each opponent 1-0 and is also assured a spot in the next round.
Germany need to defeat South Korea and hope that their goal difference is better than Sweden and/or Mexico at the end.
Advances with a win over Portugal.
Both the sides need a win on Monday to enter the Round of 16 and a loss for any of them could make life hard.
Group victor plays runner-up in Group C. Runner-up plays Group C victor.
Portugal know a win or draw against Iran would put them through.
"Messi is very good, but it is clear that he is very good because he is surrounded by extraordinary players (at Barcelona)", Simeone said, in an audio recording published by Spanish media outlets.
Tunisia and Panama have no points ahead of their meeting, where a draw would secure third place for the North Africans. France need a point to be sure of top spot.
Japan sit in the box seat here, as they meet winless, hapless and eliminated Poland on Friday at 2am.
Spain are [1.6] to top Group B, so could face Uruguay in the first knockout round, with Luis Suarez facing a few of his Barcelona team-mates.